Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance
نویسندگان
چکیده
منابع مشابه
Molecular mechanism of secretory vesicle docking.
Docking, the stable association of secretory vesicles with the plasma membrane, is considered to be the necessary first step before vesicles gain fusion-competence, but it is unclear how vesicles dock. In adrenal medullary chromaffin cells, access of secretory vesicles to docking sites is controlled by dense F-actin (filamentous actin) beneath the plasma membrane. Recently, we found that, in th...
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In regulated exocytosis, it is generally assumed that vesicles must stably "dock" at the plasma membrane before they are primed to become fusion-competent. However, recent biophysical analyses in living cells that visualize fluorescent secretory granules have revealed that exocytic behaviors are not necessarily uniform: some granules beneath the plasma membrane are resistant to Ca(2+)-triggered...
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ژورنال
عنوان ژورنال: Diabetes, Obesity and Metabolism
سال: 2007
ISSN: 1462-8902,1463-1326
DOI: 10.1111/j.1463-1326.2007.00789.x